Journal article
Retinal microvascular function predicts chronic kidney disease in patients with cardiovascular risk factors
JD Theuerle, AH Al-Fiadh, E Wong, SK Patel, G Ashraf, T Nguyen, TY Wong, FL Ierino, LM Burrell, O Farouque
Atherosclerosis | Published : 2022
Abstract
Background and aims: Endothelial dysfunction is a precursor to atherosclerosis and is implicated in the coexistence between cardiovascular disease (CVD) and chronic kidney disease (CKD). We examined whether retinal microvascular dysfunction is present in subjects with renal impairment and predictive of long-term CKD progression in patients with CVD. Methods: In a single centre prospective observational study, 253 subjects with coronary artery disease and CVD risk factors underwent dynamic retinal vessel analysis. Retinal microvascular dysfunction was quantified by measuring retinal arteriolar and venular dilatation in response to flicker light stimulation. Serial renal function assessment wa..
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Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
This study was co-funded by the National Heart Foundation of Australia Grant-in-Aid awarded to OF (G 08M 3781) and the National Health and Medical Research Council and Heart Foundation post-graduate research scholarship awarded to AAF (ID 567147) . JDT is supported by the Australian Government Research Training Program Scholarship provided by the Australian Commonwealth Government and The University of Melbourne.